Innovative high-resolution microCT imaging of animal brain vasculature

High-resolution functional magnetic resonance imaging of the animal brain.

To fully understand brain function, one must look beyond the level of a single neuron. By elucidating the spatial properties of the columnar and laminar functional architectures, information regarding the neural processing in the brain can be gained. To map these fine functional structures noninvasively and repeatedly, functional magnetic resonance imaging (fMRI) can be employed. In this articl...

Ultra-high-resolution small- animal SPECT imaging

Today the majority of clinical molecular imaging procedures are carried out with single photon emitters and gamma cameras, in planar mode and Single Photon Emission Computed Tomography (SPECT) mode. Thanks to the development of advanced multi-pinhole collimation technologies, SPECT imaging of small experimental animals is rapidly gaining in popularity. Whereas resolutions in routine clinical SP...

Innovative Methodology High-Resolution Three-Dimensional Microelectrode Brain Mapping Using Stereo Microfocal X-ray Imaging

Cox DD, Papanastassiou AM, Oreper D, Andken BB, DiCarlo JJ. High-resolution three-dimensional microelectrode brain mapping using stereo microfocal X-ray imaging. J Neurophysiol 100: 2966–2976, 2008. First published September 24, 2008; doi:10.1152/jn.90672.2008. Much of our knowledge of brain function has been gleaned from studies using microelectrodes to characterize the response properties of ...

A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging.

UNLABELLED We developed a prototype small-animal PET scanner based on depth-encoding detectors using dual-ended readout of small scintillator elements to produce high and uniform spatial resolution suitable for imaging the mouse brain. METHODS The scanner consists of 16 tapered dual-ended-readout detectors arranged in a 61-mm-diameter ring. The axial field of view (FOV) is 7 mm, and the trans...

Implantable Microsystems for High-Resolution Interfacing to the Brain